Cardiac Regeneration Therapies – Targeting Neuregulin 1 Signalling
نویسندگان
چکیده
منابع مشابه
Acute cardiac effects of neuregulin-1/ErbB signalling.
Neuregulin1 (Nrg1) is a member of the epidermal growth factor family. Its biological effects are mediated by the ErbB family of receptor tyrosine kinases (ErbB2, ErbB3, and ErbB4). Nrg1/ErbB signalling is an essential paracrine mediator of cell–cell interactions that are indispensable for cardiac development but also play a crucial role in the adult heart. In the foetal heart, Nrg1 is produced ...
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Evidence from genetic, transgenic and post-mortem studies has strongly supported the critical role that neuregulin 1 (NRG1) and its ErbB4 receptor plays in the pathophysiology of schizophrenia. This article aims to review current evidence regarding the effects of antipsychotic treatment on NRG1-ErbB4 signalling. NRG1 and ErbB4 knockout mice display abnormal behaviours relevant to certain featur...
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Identifying the signalling pathways underlying the pathophysiology of schizophrenia is an essential step in the rational development of new antipsychotic drugs for this devastating disease. Evidence from genetic, transgenic and post-mortem studies have strongly supported neuregulin-1 (NRG1)-ErbB4 signalling as a schizophrenia susceptibility pathway. NRG1-ErbB4 signalling plays crucial roles in ...
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Cardiovascular disease is a major cause of mortality worldwide. Although death rates associated with cardiovascular disease in general have declined over the past decades, the prevalence and incidence of heart failure (HF) are increasing. The increasing incidence has led to the increasing economic burden of the condition, estimated to be $108 billion per annum in 2012. Current standard medical ...
متن کاملMeta-Analyses of Human Cell-Based Cardiac Regeneration Therapies
The Meta-Analysis of Cell-Based Cardiac Studies (ACCRUE) consortium recently published the results of the first prospective individual patient data (IPD)–based meta-analysis that included 12 randomized clinical trials investigating 1-year outcomes in patients with recent STsegment–elevation myocardial infarction (STEMI), who received intracoronary autologous stem and progenitor cells. This IPD ...
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ژورنال
عنوان ژورنال: Heart, Lung and Circulation
سال: 2016
ISSN: 1443-9506
DOI: 10.1016/j.hlc.2015.08.014